The World’s First ‘Heart-Thymus’ Transplant Is Performed on A Baby

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Image Courtesy: BBC

According to physicians, Easton, a little boy from the United States, is the first child in the world to have a simultaneous heart and thymus transplant.

The doctors hope that the revolutionary technique, which did to save his life, would transform the area of organ transplantation. Thanks to the donated thymus tissue, his body should not reject the replacement heart. Easton is doing well months after his operation, according to testing. The thymus tissue is functioning, which means his body is producing critical immune cells, perhaps reducing or eliminating the need for him to take anti-rejection medicines for the rest of his life.

“We are extremely enthusiastic about it,” said one of his physicians, Duke University Hospital’s Joseph Turek. Tolerance has long been the holy grail of transplantation, and we are finally on the verge of achieving it. “In the future, this has the potential to revolutionize the face of solid organ transplantation.” T-cells combat foreign substances in the body, and the thymus gland aids in their growth. It instructs these immune cells on what is and is not “self,” hence what may be attacked. Easton’s physicians feel that giving him cultured thymus tissue from the same donor who gave him a heart would aid his body’s acceptance of the new tissues.

The Tale of Easton

Easton was born with a weakened heart as well as multiple immune system issues. He spent the first seven months of his life in the hospital, part of it on life support, and he had many heart procedures as well as antibiotics for repeated illnesses that his body couldn’t fight on its own. “It helped slightly,

Image Courtesy: BBC

but it was essentially a Band-Aid for us to get it through transplant,” his mother, Kaitlyn Sinnamon, says. His physicians sought the FDA, the medical regulatory authority, to carry out an experimental form of transplant that, as far as they knew, had never been done in combination before. Because Easton required a new heart and, separately, a new thymus gland, the FDA approved the surgeries, which took place in August 2021, when Easton was six months old.

According to Dr. Turek, “It was completely coincidental. We were qualified to accomplish both. “The research we did in the lab focused on utilizing the thymus in conjunction with heart transplantation to create tolerance – in other words, retraining the immune system and having the same donor’s thymus and heart grow up together. “For Easton, we saw this as a great chance. If this succeeds, it might eventually be extended to all solid organs.”

Before then, much more study is required, including determining if it is possible to remove and replace the thymus in patients who currently have an entirely functional one. In addition, Easton’s medical team intends to wean him off the immunosuppressive medicines at some time in the future to observe how he responds. “I hope that when he grows older, he gets to be proud of his scars and realizes that he not only got to save his own life, but he also got to save the lives of others,” Kaitlyn added. The successful transplant surely is a leap forward in the field of organ transplantation.

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